QGridLayout

class PyQt5.QWidgets.QGridLayout

layout = QGridLayout()

addWidget(widget, row, columnt, row_span=1, column_span=1)

layout.addWidget(QPushButton('Left'), 0, 0)
layout.addWidget(QPushButton('Right'), 0, 1)
layout.addWidget(QPushButton('Span 2 columns'), 1, 0, 1, 2)